Planning a trip to Central America and Caribbean? Perhaps you'd like to visit some of the continent's most popular travel destinations, like Panama. Agoda.com offers the best prices for hotels in Panama, with 395 hotels ready for instant reservation via our secure online booking engine. Consisting of 13 regions, each with its own unique appeal, the country offers visitors plenty of different areas to explore. While any city is sure to excite, Panama City, Boquete, Bocas del Toro go above and beyond to capture your attention. Sweet deals are just a click away when you use Agoda.com to book your next trip to Panama.