Rio Negro is one of the 19 regions of Uruguay that travelers like to visit. Search for special offers from over 7 hotels on Agoda.com. The great Rio Negro is teeming with tourist attractions and popular cities such as Fray Bentos, San Javier, Nuevo Berlin. Getting around Rio Negro is easy with the Department's major airports as access points to major cities. With availability in more than 22,000 cities worldwide, more travelers today are choosing Agoda.com to search for hotels in Rio Negro.