Whether it's your first visit or your fiftieth, Santa Cruz is a great destination for a vacation. Agoda.com offers big savings on 173 hotels in top locations. While in Santa Cruz, be sure to visit El Calafate, El Chalten, Monte Dinero. Our website has been designed to help you discover exciting and interesting things to do and places to see. Getting around Santa Cruz is easy with the Province's major airports as access points to major cities. With more than 2 million customer reviews, more travelers are choosing Agoda.com to book hotels in Santa Cruz.