Enter your dates to check availability and book this hotel

Twenty One Hotel

23 Cola Di Rienzo Street, Vatican, Rome, Italy 00192 (Show on map)

Book now!

"Location is really good you can walk to vatican or use bus..."

  • Atrin, United States
  • August 18, 2015
  • Area: Location: Vatican
  • Rooms : 86

Room Types
Double With Breakfast
Twin With Breakfast
Double For Single Use with Breakfast
Double With Breakfast Non Refundable
Double For Single Use
Triple With Breakfast
Deluxe With Breakfast


When would you like to stay at this hotel?

Features of Twenty One Hotel

24-hour front desk

24-hour room service

airport transfer


bicycle rental

business center

car park


daily housekeeping


facilities for disabled guests

family room

laundry service

luggage storage



room service

safety deposit boxes


shuttle service

smoking area



free Wi-Fi in all rooms

Wi-Fi in public areas


car park


Book now!

Sale ends soon!

A clean and modern hotel, guests at this boutique property enjoy the convenience of space. You can easily walk to the Vatican and Castel St. Angelo in one direction and Piazza del Popolo and the Spanish Steps in the other. The closest subway station is just 300 meters from the hotel, making it easy for guests to discover attractions spread across this historic city. Stay here once, and you are sure to pick Twenty One Hotel the next time you are in Rome. Please enter your preferred dates of stay and submit our online booking form to make a reservation at Twenty One Hotel.
As of January 1st 2011, the Municipal Council of Rome has introduced a room occupancy tax in the amount of maximum EUR 3.00 per person per night – applicable for maximum 10 days. Starting from September 1st, 2014 the amount has been increased up to EUR 7.00 per person per night (depending on the accommodation type and star rating). Children under the age of 10 years are exempt from payment. The fee will be asked of anyone staying in overnight accommodation inside Rome’s boundaries at the end of each stay. The fee is not included in Agoda's price and must be paid at the Hotel.

Children and extra beds:
Infant 0-1 year(s)
Stay for free if using existing bedding. Note, if you need a cot there may be an extra charge.
Children 2-3 year(s)
Must use an extra bed

Guests over 3 years old are considered as adults.

Extra beds are dependent on the room you choose, please check the individual room policy for more details.

When booking more than 5 rooms, different policies and additional supplements may apply.

Check-In From
2:00 PM

Check-Out Until
11:00 AM

Distance from City Center
1. Km

Number of Floors

Number of Rooms

Parking Fee (per day)
25 EUR

Room Voltage

Time to Airport (Minutes)

Year Hotel Built

Recent customer comments

Filter by Traveler Type


Very Good


from 95 reviews

53 reviews in English

Value for Money
Staff Performance
Hotel Condition/Cleanliness
Room Comfort/Standard
All reviews (95)
Sort by:
Atrin S. Couples United States of America, August 18, 2015
Great hotel and good location

Location is really good you can walk to vatican or use bus to go the other part of town. The breakfast is good. Staffs are friendly and helpful
My wife and i had a great and Memorial stay in this Hotel
Report this review
Kellyanne B. Couples United Kingdom, July 19, 2015
Great location, very modern decor, lovely staff

Location was excellent, friendly staff and amenities in hotel where good
We stayed in the hotel for 4 nights in July, decor was lovely and very central location for site seeing, rooms cleaned every day and staff always friendly/helpful throughout staff. Only a few things I would comment on, the room was smaller than in the pics and no mention on city tax on arrival would be good to remind guests on arrival that this is paid on departure, other than this was a great hotel and would stay again
Report this review
Tonny H. Families with older children Indonesia, February 23, 2015
That was a good hotel, clean and good location

Clean, good location and minimalis
It was good, specially the location
Report this review
1 - 10 of 53 reviews Next page

Book now!

Sale ends soon!

What's nearby? / Directions

What's nearby?
  • Saint Peter's Cathedral - 1.3 kilometers
    Piazza di Spagna - 1.1 kilometers
    Piazza Navona - 1.2 kilometers
    Trevi Fountain - 1.5 kilometers
    Roma Termini - 2.7 kilometers

Customers who looked at this Hotel were also interested in......

Starhotels Metropole

Starhotels Metropole

Fantastic 8.1

from 103 reviews

Bettoja Mediterraneo Hotel

Bettoja Mediterraneo Hotel

Very Good 7.7

from 112 reviews

Hotel Area: Termini Central Station

room was large and clean, breakfast was great, location excellent. Edward, United States of America September 14, 2015
Hotel La Rovere

Hotel La Rovere

Fantastic 8.2

from 14 reviews

Hotel Area: Vatican

Friendly staff, location, good breakfast. Whitney, Australia May 13, 2015
People love this hotel for:
Nearest transport:
  • Lepanto Underground Metro Station (0.4 Km)
Area recommended for:
  • culture
  • religious interests
  • sightseeing
Distance to airport:
  • Ciampino–G. B. Pastine International Airport (16.0 Km)
  • Leonardo da Vinci-Fiumicino Airport (20.9 Km)
Customer comments:
  • "Close to shopping area" , "Good location" , "Nice hotel"
Top nearby attractions:
  • Piazza del Popolo (0.6 Km)
  • Castel Sant'Angelo (0.7 Km)
  • Via del Corso (1.1 Km)
  • St Peter's Square (1.2 Km)

Customer Support