A clean and modern hotel, guests at this boutique property enjoy the convenience of space. You can easily walk to the Vatican and Castel St. Angelo in one direction and Piazza del Popolo and the Spanish Steps in the other. The closest subway station is just 300 meters from the hotel, making it easy for guests to discover attractions spread across this historic city. Stay here once, and you are sure to pick Twenty One Hotel the next time you are in Rome. Please enter your preferred dates of stay and submit our online booking form to make a reservation at Twenty One Hotel.