Whether it's your first visit or your fiftieth, Comayagua is a great destination for a vacation. Agoda.com offers big savings on 13 hotels in top locations. While in Comayagua, be sure to visit Siguatepeque, Comayagua. Our website has been designed to help you discover exciting and interesting things to do and places to see. The Department receives many visitors due to its unique and interesting features. More travelers are choosing Agoda.com to book accommodation in Comayagua, with over 170,000 hotels worldwide.