Santa Cruz is one of the 24 regions of Argentina that travelers like to visit. Agoda.com offers big savings on 224 hotels in top locations. Our instant confirmation gives you piece of mind and more time explore popular cities such as El Calafate, El Chalten, Lago San Martin. Just as it has hotel options to suit every pocket, Santa Cruz has activities to suit every interest. More travelers are choosing Agoda.com to book accommodation in Santa Cruz, with over 170,000 hotels worldwide.